Research At COMSATS

Natural Product Chemistry

Dr. Farhan A. Khan

	Designation:	Associate Professor
	Email:	farhankhan@cuiatd.edu.pk
	Phone No. :	N/A
	Role:	Faculty
	Research Interests:	Interested in the synthesis of: Modified Peptides Heterocyles Biologically active molecules (metal complexes) Enable GingerCannot connect to Ginger Check your internet connection or reload the browserDisable in this text fieldRephraseRephrase current sentenceEdit in Ginger×

Academics/ Degrees

PhD, University of Technology Vienna, Austria, 2012
M.Sc., Islamia University Bahawalpur, Pakistan, 2005
B.Sc., Islamia University Bahawalpur, Pakistan, 2002

Profile/Bio

PROFESSIONAL AND RESEARCH EXPERIENCE

April 11, 2022 to date: Tenured Associate Professor, Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus Pakistan
2012 to April 10, 2022: Assistant Professor, Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus Pakistan

Projects

Facile Synthesis Of Substituted Carbohydrazide Building Blocks

Synthesis And Photocatalyticc Properties Of Titanium Phthacyanines Axially Substituted With Tetracyanoquinodimethane And Its Derivatives

Modified Activity Of Commercially Available Antibiotic Drugs By Making Gold Nano-Particle Conjugates.

Synthesis Of Biologically Active Coumarin Derivatives By Palladium Catalysed Cross Coupling Reaction

Design, Synthesis And Characterization Of Biologically Active Coumarine Derivatives

Studies Of 2-Arylbenzothiazoles Derivatives As Antifungal Agents: A Green Synthetic Approach

Design, Synthesis And Characterization Of 4-Aminoantipyrine Derivatives

Publications/Papers

2023

Journal

Abida K Khan,Ghulam Murtaza,Tauqir A. Sherazi,Farhan Khan,Shujaat A.K, SA Khan "Antibacterial and wound healing potential of electrospun PVA/MMT nanofibers containing root extract of Berberis lycium" , Journal of Drug Delivery Science and Technology ,Volume 79 ,Page 103987 , 2023

S. Ali,S. M. Bukhari,M. Jahangir,A. Zaidi,Farhan Khan,M. Riaz,M. M. Khan,S. Sammi,I. u-llah,A. Amin "Moxifloxacin metal complexes; synthesis, characterization, antimicrobial and antidiabetic activities with docking studies" , Bioinorganic Chemistry and Applications ,Volume 2023 ,Issue 3754561 ,Page 1-15 , 2023

S. M. Bukhari,A. Zaidi,R. Sarwar,M. Ali,Farhan Khan,U.Farooq,J. Uddin,A. Ibrar,A. Khan,A. Al-Harrasi "Some of the organic ligand transition metal complexes can serve as potent α-glucosidase inhibitors: in-vitro, kinetics and in-silico studies" , Inorganic and Nano-Metal Chemistry , 2023

2022

Journal

A. Saleem,U.Farooq,S. Khan,Ahson J. Shaikh,Sohail Anjum Shahzad,Farhan Khan,A. Zaidi,S. M. Bukhari,R. Sarwar,T. A. Wani,S. Mahmud,M. Israr "Isoxazole Derivatives Against Carbonic Anhydrase: Synthesis, Molecular Docking, MD simulations, free energy calculations coupled with In-vitro Studies" , ACS Omega ,Volume 7 ,Page 30359-30368 , 2022

Farhan Khan "Chitosan-based Dy2O3/CuFe3O4 Bio-nanocomposite Development, Characterization, and Drug Release Kinetics" , International Journal of Biological Macromolecules ,Volume 220 ,Issue 1 ,Page 788-801 , 2022

Farhan Khan "Inhibitory Efficacy of Thiosemicarbazones for Carbonic Anhydrase II (Bovine and Human) as a Target of Calcification and Tumorigenicity" , Current Pharmaceutical Design ,Volume 28 ,Issue 36 ,Page 3010-3022 , 2022

Book/Chapter

Farhan Khan "Cultural and Socio-Economic Perspective of Some Promising Edible Plants from Northern Pakistan" , Edible Plants in Health and Diseases , 2022

2021

Journal

A. Khan,M. Ahmad,M. Ali,U.Farooq,Farhan Khan,S. M. Bukhari "Antiglycation potential of indigoferin A, indigoferin B and indigoferin C natural products from Indegofera heterantha Brandis" , Clinical Phytoscience ,Volume 7 ,Issue 5 ,Page 1-6 , 2021

Maria Bibi,U. Rashid,U.Farooq,Farhan Khan,Naveeda AkhterQureshi,Abdul Sadiq,------ "Exploring the ability of dihydropyrimidine-5-carboxamide and 5- benzyl-2,4-diaminopyrimidine-based analogues for the selective inhibition of L. major dihydrofolate reductase" , European Journal of Medicinal Chemistry ,Volume 210 ,Page 112986 , 2021

Farhan Khan "Finding New Precursors for Light Harvesting Materials: A Computational Study of the Fluorescence Potential of Benzanthrone Dyes" , ACS Omega ,Volume 6 ,Issue 47 ,Page 32334–32341 , 2021

Ubaid Ullah,Abdur Rauf,Eman El-Sharkawy,Farhan Khan,Ajmal Khan,S. M. Bukhari "Green synthesis, in vivo and in vitro pharmacological studies of Tamarindus indica based gold nanoparticles" , Bioprocess and Biosystems Engineering ,Volume 44 ,Issue 6 ,Page 1185-1192 , 2021

Mughisa Munir,Syed Nisar Hussain Shah,Uzma Almas,Farhan Khan,A. Zaidi,S. M. Bukhari,Ghulam Murtaza "An assessment of the wound healing potential of a herbal gel containing an Azadirachta indica leaf extract" , Veterinarni Medicina ,Volume 66 ,Issue 3 ,Page 99-109 , 2021

2020

Journal

M.T. Shehzad,A. Khan,M. Aslam,S.A. Halim,M. Khiat,M.U. Anwar,Farhan Khan "Synthesis, characterization and molecular docking of some novel hydrazonothiazolines as urease inhibitors" , Bioorganic Chemistry ,Volume 94 ,Page 103404 , 2020

M. Ali,S. M. Bukhari,A. Zaidi,Farhan Khan,U. Rashid,N. Tahir,B. Rabbani,U.Farooq "Inhibition Profiling of Urease and Carbonic Anhydrase II by high-throughput Screening and Molecular Docking Studies of Structurally Diverse Organic Compounds" , Letters in Drug Design & Discovery , 2020

Afia Saleem,S. M. Bukhari,A. Zaidi,U.Farooq,Majid Ali,Asma Khan,Kausar Hussain Shah,Adeem Mahmood,Farhan Khan "Enzyme inhibition and antibacterial potential of 4-hydroxycoumarin derivatives" , Brazilian Journal of Pharmaceutical Sciences ,Volume 56 ,Issue 1 ,Page 1-10 , 2020

2019

Journal

M. Alam,A. Khan,A. Wadood,S. Bashir,A. Aman,U.Farooq,Farhan Khan,F. Mabood,Samiullah,A. Al-Harrasi "Bioassay-guided isolation of urease inhibitors from Ferula narthex Bioss" , South African Journal of Botany ,Volume 120 ,Page 247-252 , 2019

Abdul Sadiq,Anwar Zeb,Sajjad Ahmad,Farhat Ullah,Muhammad Ayaz,Farman Ullah,Nawab Ali,Jamshaid Ahmad,Farhan Khan "Evaluation of crude saponins, methanolic extract and subsequent fractions from Isodon rugosus Wall. ex Benth: Potentials of antiangiogenesis in egg and anti-tumorigenesis in potato" , Pakistan Journal of Pharmaceutical Sciences ,Volume 32 ,Issue 5 ,Page 1971-1977 , 2019

M. Ubaid,M. Ahmad,Farhan Khan,G. Murtaza "Development, Validation, and Application of HPLC Method for Metformin in Rabbit Plasma" , Current Pharmaceutical Analysis ,Volume 15 ,Issue 6 ,Page 574-579 , 2019

Conference

Farhan Khan,A. Zaidi,S. M. Bukhari,Ayesha Nisar "Synthesis of bis(4-hydroxy-2H-chromen-2-one) derivatives and their antibacterial potential" , International Chemistry Conference Forefronts of Chemistry Celebrating the Periodic Table Year , 2019

A. Zaidi,S. M. Bukhari,Farhan Khan,Tehmina Tariq "Synthesis of thiazole analogues and their antibacterial potential" , International Chemistry Conference Forefronts of Chemistry Celebrating the Periodic Table Year” held in Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, Pakistan , 2019

Farhan Khan,S. M. Bukhari,A. Zaidi,Sajida Bano "Synthesis of sulfonylhydrazide derivatives and their antibacterial activities" , International Chemistry Conference Forefronts of Chemistry Celebrating the Periodic Table Year” held in Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, Pakistan , 2019

Farhan Khan,S. M. Bukhari,A. Zaidi,Ramla Khattak "Synthesis of 4-hydroxycoumarin derivatives and their antibacterial activity" , International Chemistry Conference Forefronts of Chemistry Celebrating the Periodic Table Year” held in Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, Pakistan , 2019

Farhan Khan,A. Zaidi,S. M. Bukhari,Muneer Ahmed "Synthesis of ciprofloxacin metal complexes and their antibacterial potential" , International Chemistry Conference Forefronts of Chemistry Celebrating the Periodic Table Year” held in Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, Pakistan , 2019

R. Sarwar,Mohsin Ali Khan,,U.Farooq,N. Riaz,Sadia Naz,Farhan Khan "Investigation of Biological Potential of Verbena officinalis by its Total Phenolic Content Antibacterial, Antioxidant, NO Scavenging Activities." , 8th International Conference ES-Dev 2019. (h-HSE-13). p.147. , 2019

2018

Journal

B. Ahmad,S. Naz,A. Rauf,S. Bashir,A. Khan,U.Farooq,Farhan Khan,S. Patel,Z. Khan,J. Hussain,A. Al-Harrasi "In vivo study on analgesic, gastrointestinal tract (GIT) motility, and anti-termite potential of methanolic extract of Sarcococca saligna (D. Don) Muell. fruits" , South African Journal of Botany ,Volume 114 ,Page 40-43 , 2018

Farhan Khan,Sidra Mushtaq,Sadia Naz,U.Farooq,A. Zaidi,S. M. Bukhari,Abdur Rauf,Mohammad S. Mubarak "Sulfonamides as potential bioactive scaffolds" , Current Organic Chemistry ,Volume 22 ,Issue 8 ,Page 818-830 , 2018

M. Alam,A. Khan,A. Wadood,S. Bashir,A. Aman,U.Farooq,Farhan Khan,F. Mabood,J. Hussain,Samiulah,A. Al-Harrasi "Bioassay-guided isolation of urease inhibitors from Ferula narthex Bioss" , South African Journal of Botany ,Volume 120 ,Page 247-252 , 2018

Conference

Farhan Khan,A. Zaidi,S. M. Bukhari,Kiran Shehzadi "Synthesis and antibacterial evaluation of 4-aminocoumarin Schiff bases" , 10th Chemistry Conference on Chemistry in Engineering & Life Sciences (CELS-2018)” held in Chemistry Division Pakistan Institute of Nuclear Science and Technology (PINSTECH), Islamabad, Pakistan , 2018

S. M. Bukhari,A. Zaidi,Farhan Khan,Iqra Kalsoom "Synthesis of pyrazolone Schiff bases and their antibacterial potential" , 10th Chemistry Conference on Chemistry in Engineering & Life Sciences (CELS-2018)” held in Chemistry Division Pakistan Institute of Nuclear Science and Technology (PINSTECH), Islamabad, Pakistan , 2018

2017

Journal

A. Rauf,G. Uddin,B. S. Siddiqui,A. Khan,U.Farooq,Farhan Khan,S. M. Bukhari,S. B. Khan "Bioassay-guided isolation of novel and selective urease inhibitors from Diospyros lotus" , Chinese Journal of Natural Medicines ,Volume 15 ,Issue 11 ,Page 865-870 , 2017

Prof. Dr. M. Gulfraz,Muntazir Shah,Hina gul,S. M. Bukhari,Kashif Ashraf,M. Azeem,Farhan Khan "Anti-tuberculosis potential, pharmacological and phytochemical studies of methanolic extracts from selected plant species " , Acta Poloniae Pharmaceutica-Drug Research ,Volume 74 ,Issue 6 ,Page 1761-1766 , 2017

A. Ibrar,Shamyla Nawazish,Imtiaz Khan,Tayyaba Noor,Bushara Uzair,S. M. Bukhari,Farhan Khan,A. Zaidi "Triazolothiadiazines as a new class of efficient DNA of intercalating agents" , Acta Poloniae Pharmaceutica - Drug Research ,Volume 74 ,Issue 5 ,Page 1405-1411 , 2017

Saeed Muhammad,Awan A. Aleem,Naveed Muhammad,Mehmod Khalid,A. Khan,U.Farooq,Izhar Ahmad,Farhan Khan,S. M. Bukhari "Investigation of antipyretic activity of Viola serpens on brewer’s yeast induced pyrexia in mice" , Acta Poloniae Pharmaceutica - Drug Research ,Volume 74 ,Issue 06 ,Page 1797ñ1802 , 2017

Shaista Hameed,Linda A. Lawton,Christine Edwards,Ajmal Khan,U.Farooq,Farhan Khan "Effects of temperature and salinity on the production of cell biomass, chlorophyll-a and intra- and extracellular nodularins (NOD) and nodulopeptin 901 produced by Nodularia spumigena KAC 66" , J. Appl. Phycol. ,Volume 29 ,Page 1801 , 2017

Sajjad Ali,A. Zaidi,Farhan Khan,Jamil Khan,Muhammad Bhaktiar,S. M. Bukhari "Applications of ultrasound and industrial processes" , Pakistan Journal of Contemporary Sciences A Multidisciplinary Journal ,Volume 2 ,Issue 1 ,Page 1-17 , 2017

Farhan Khan,Sidra Mushtaq,Sadia Naz,U.Farooq,A. Zaidi,S. M. Bukhari,Abdur Rauf,Mohammad S. Mubarak "Sulfonamides as potential bioactive scaffolds" , Current Organic Chemistry , 2017

Conference

Farhan Khan,Kiran Shehzadi,S. M. Bukhari,A. Zaidi,Muhammad Aamir "Antibacterial potential of N-substituted indole derivatives" , Two Days Conference on Recent Advances in Chemistry held at Department of Chemistry, The University of Lahore, Pakistan , 2017

Farhan Khan,Iqra Kalsoom,A. Zaidi,Sundus Mir,S. M. Bukhari "Synthesis and Characterization of Biguanide Derived Compounds" , Two Days Conference on Recent Advance in Chemistry (2017) held in Department of Chemistry, The University of Lahore, Pakistan. , 2017

S. M. Bukhari,Anee Taj,A. Zaidi,U. Rashid,Farhan Khan "Biological Evaluation of Some New Derivatives of 4-aminoantipyrine" , 9th Chemistry Conference 2017 on Chemistry in Engineering and Life Sciences at Chemistry Division, PINSTECH, Islamabad , 2017

Farhan Khan,Afia Saleem,S. M. Bukhari,A. Zaidi "Synthesis of 4-Hydroxycoumarin Derivatives in Search of Biologically Active Molecules" , 9th Chemistry Conference 2017 on Chemistry in Engineering and Life Sciences at Chemistry Division, PINSTECH, Islamabad , 2017

Farhan Khan,Iqra Kalsoom,A. Zaidi,S. M. Bukhari "Synthesis and characterization of Metformin Derivatives" , 9th Chemistry Conference 2017 on Chemistry in Engineering and Life Sciences at Chemistry Division, PINSTECH, Islamabad , 2017

Farhan Khan,Kiran Shehzadi,A. Zaidi,K.H. Shah,S. M. Bukhari "Synthesis of New Isatin Derivatives in Search of Antibacterial Molecules" , 9th Chemistry Conference 2017 on Chemistry in Engineering and Life Sciences at Chemistry Division, PINSTECH, Islamabad , 2017

2016

Journal

A.Maalik,S. M. Bukhari,A. Zaidi,Kausar Hussain Shah,Farhan Khan "Chlorogenic acid: a pharmacologically potent molecule" , Acta poloniae pharmaceutica-Drug Research ,Volume 73 ,Issue 4 ,Page 851-854 , 2016

Farhan Khan,A.Maalik,G. Murtaza "Inhibitory Mechanism Against Oxidative Stress of Caffeic Acid" , Journal of Food and Drug Analysis ,Volume 24 ,Issue 2016 ,Page 695-702 , 2016

Conference

Farhan Khan,S. M. Bukhari,A. Zaidi,K.H. Shah,Basit Niaz,Fatima Aslam "Synthesis and characterization of substituted hydrazones from 4-hydroxycoumarin" , 2nd Multi-Disciplinary Students Research Conference (MDSRC – 2016)Office of Research, Innovation and Commercialization (ORIC), held in University of Wah, Wah Cantt., Pakistan (20.12.2016 to 21.12.2016). , 2016

Farhan Khan,Afia Saleem,S. M. Bukhari "Synthesis of carbohydrazide based building blocks" , 8th Chemistry Conference 2016 on Chemistry in Engineering and Life Sciences” held in Chemistry Division Pakistan Institute of Nuclear Science and Technology (PINSTECH), Islamabad, Pakistan , 2016

Farhan Khan,Anee Taj,A. Ibrar,S. M. Bukhari "Antibacterial potential of new derivatives of 2,4-Dinitrophenyhydrazine" , 8th Chemistry Conference (2016) on Chemistry in Engineering and Life Sciences at Pakistan Institute of Nuclear Science and Technology (PINSTECH) Islamabad, Pakistan. , 2016

Farhan Khan,S. M. Bukhari,Mohsin Danish "Design, Synthesis and Computational Studies of Benzanthrone Derivatives" , 27th National and 15th International Chemistry Conference (2016) at Institute of Chemistry, University of Malakand, Pakistan , 2016

2015

Journal

Farhan Khan,A.Maalik,Tayyaba Noor,A. Zaidi,U.Farooq,S. M. Bukhari " Advances in Pharmacology of Isatin and its Derivatives: A Review" , Tropical Journal of Pharmaceutical Research ,Volume 14 ,Issue 10 ,Page 1937-1942 , 2015

A. Zaidi,S. M. Bukhari,Farhan Khan,Tayyaba Noor,Naseem Iqbal "Ethnobotanical, Phytochemical and Pharmacological Aspects of Daphne mucronata (thymeleaceae) " , Tropical Journal of Pharmaceutical Research ,Volume 14 ,Issue 8 ,Page 1517-1523 , 2015

Muhammad Atif,Iftikhar Ali,Ajaz Hussain,Farhan Khan,Viqar Hyder,A.Maalik,U.Farooq "Pharmacological assessment of natural bioactive flavone: Hispidulin " , Acta Poloniea Pharmaceutica-Drug Research ,Volume 72 ,Issue 5 ,Page 829-842 , 2015

2014

Journal

Farhan Khan,T. Mahmood,Muhammad Ali,Abdul Saeed ,A.Maalik "Pharmacological importance of an ethnobotanical plant; Capsicum annuum (L)" , Natural Product Research ,Volume 28 ,Issue 16 ,Page 1267-1274 , 2014

A.Maalik,Farhan Khan,A.Mumtaz,A.Mahmood,M. Atif,S.Azhar "Pharmacological Applications of Quercetin and its Derivatives: A Short Review" , Tropical Journal of pharmaceutical Reseach ,Volume 13 ,Issue 9 ,Page 1561-1566 , 2014

G. Murtaza,S.Azhar,A.Mumtaz,A.Maalik,Farhan Khan "Recent pharmacological advancements in schiff bases: A review" , Acta Poloniae Pharmaceutica-Drug Research ,Volume 71 ,Issue 4 ,Page 531-535 , 2014

T. Mahmood,Farhan Khan "DFT Studies of Biphenyl Derivatives,Potential Application as Chiral Dopants for Liquid Crystals" , Journal of Chemical Society of Pakistan ,Volume 36 ,Issue 3 ,Page 498-502 , 2014

2013

Journal

Farhan Khan,Constantin Rabong, Ulrich Jordis, Jaywant Phopase "Surprising behavior of NXO-peptides toward the lithium hydroxide solvolysis" , Tetrahedron Letters ,Volume 54 ,Issue 28 ,Page 3679-3682 , 2013

Farhan Khan,A.Maalik,Z. Iqbal,I.Malik "Recent pharmacological developments in β-carboline alkaloid "harmaline"" , European Journal of Pharmacology ,Volume 721 ,Page 391-394 , 2013

Awards/ Appreciations

2007: Scholarship award under Indigenous Scholarship Program for Ph.D. by Higher Education Commission of Pakistan to support my Ph.D. at Islamia University of Bahawalpur, Pakistan
2008: Scholarship award under Indigenous Scholarship Program for Ph.D. by Higher Education Commission of Pakistan to support my Ph.D. at University of Technology Vienna, Austria