In this study the self-microemulsifying drug delivery systems (SMEDDS)of poorly water-soluble drugs (anticancer, antifungal, antihypertensive, NSAIDs, antipsychotics etc) will be developed to increase the drug solubility and absorption in GIT. SMEDDS have been known for their numerous advantages like spontaneous formation, ease of manufacture, stability, and improved solubilization, faster release rates and better availability in the blood, which leads to lesser drug dose, lower cost, and reduced stomach irritation and toxicity; thus ultimately improving drug acceptance by the consumers. SMEDDS will be prepared and evaluated in comparison with other commercially available medicines for blood concentration in mice. Thus, safe and highly cost effective formulations of water insoluble drugs will be developed which will be new hope for patients and an attraction for pharmaceutical industry.