Phytotherapy is a very common practice in Pakistan. Literature survey exhibited lack of reports addressing toxicological actions of herbs frequently used in Pakistan. Considering this, the present study is designed to explore the systemic toxicity of herbs. To begin with, the local market, herbalists and industrial herbal products will be surveyed to identify the herbs used often by our peoples. The top three utilized herbs will be evaluated for their toxicological potential using repeated dose toxicity (food and water consumption, weight variation, hematology, blood chemistry and urinalysis) as per regulatory requirement by food and drug administration (FDA). The data obtained through this study will help protecting our peoples from the toxic effects of these herbs thereby improving their socio-economic status. Additionally, this study will reduce the burden on our health care system.