Introduction

Colloidal Silica has been attracting the attention of colloidal scientists since a very long time. A popular method of the synthesis of colloidal silica was first established by Stober in 60’s[1]. The method has been modified many a times according to the needs[2]and still the most popular and established method of choice for the preparation of colloidal sililca[3-5]. Many research groups have synthesized porous silica particles which are colloidal in nature [6-10]. Here we propose to use a modified form of stobers method for the synthesis of colloidal silica particles which might be used for the encapsulation of an additive in the particles. The additive could be a dye whose presence can be simply detected by a UV-Visible spectroscopy. Same instrument can be used to check the encapsulation efficiency by calculating change in concentration of the dissolved additive before and after encapsulation. 

References

1.            Stöber, W., A. Fink, and E. Bohn, Controlled growth of monodisperse silica spheres in the micron size range. Journal of Colloid and Interface Science, 1968. 26(1): p. 62-69.

2.            Wong, Y.J., et al., Revisiting the stober method: inhomogeneity in silica shells. Journal of the American Chemical Society, 2011. 133(30): p. 11422-11425.

3.            Kobayashi, Y., et al., Silica coating of silver nanoparticles using a modified Stöber method. Journal of Colloid and Interface Science, 2005. 283(2): p. 392-396.

4.            Li, W. and D. Zhao, Extension of the Stöber Method to Construct Mesoporous SiO2 and TiO2 Shells for Uniform Multifunctional Core–Shell Structures. Advanced Materials, 2013. 25(1): p. 142-149.

5.            Liu, W.B., et al., Synthesis of Magnetic Particles and Silica Coated Core-Shell Materials. Advanced Materials Research, 2013. 631: p. 490-493.

6.            Lin, Y.-S. and C.L. Haynes, Synthesis and characterization of biocompatible and size-tunable multifunctional porous silica nanoparticles. Chemistry of Materials, 2009. 21(17): p. 3979-3986.

7.            Nandiyanto, A.B.D., et al., Influences of Surface Charge, Size, and Concentration of Colloidal Nanoparticles on Fabrication of Self-Organized Porous Silica in Film and Particle Forms. Langmuir, 2013.

8.            Ray, S., et al., Porous silica nanoparticles with mesoscopic void spaces for the domino intermolecular aerobic oxidative synthesis of novel β, β′-diketoenamines. Catalysis Science & Technology, 2013.

9.            Slowing, I.I., et al., Mesoporous silica nanoparticles for drug delivery and biosensing applications. Advanced Functional Materials, 2007. 17(8): p. 1225-1236.

10.          Wu, S.-H., C.-Y. Mou, and H.-P. Lin, Synthesis of mesoporous silica nanoparticles. Chemical Society Reviews, 2013.