1.   Abstract

Biologically active 2-Arylbenzothiazoles derivatives has drawn interest towards synthesis of their new derivatives. Thiazole and its derivatives exist in a variety of natural products and a number of biologically active compounds.

2.   Literature Review and  Description

It is class of potent and selective antitumor agents which exhibit nanomolar inhibitory activity against a range of cancer cell lines i.e. human breast, colon and renal cell lines. Substituted thiazoles are an important class of biologically active compounds and are known to show a range of pharmacological activities like anti-tubercular, anti-parasitic, antimicrobial, anticancer etc. In addition, they possess significant utility as imaging agents for β-amyloid, chemiluminescent agents, calcium channel antagonists and photosensitizers.

Recently, benzothiazoles derivatives have been reported to show a competitive antifungal activity against Botrytis cinera as compared to commercially available fungicide Triadimefon; these compounds even has the potential to replace commercially available aryl-2-mercaptobenzothiazoles in agrochemicals.

Cyclooxygenase (COX) enzymes are involved in the production of prostaglandins which are subsequently involved in the cause of inflammation. There are two types of COX enzymes i.e. COX-1 and COX-2; whereas, COX-2 is selectively involved in causing inflammation. Currently, available marketed drugs NSAID’s are not selective inhibitors and inhibition of COX-1 cause ulceration; therefore, new selective inhibitors for COX-2 are required for more efficient treatment. Benzothiazole derivatives has been stated as active agents against COX-2 inhibition.

It is evident from the literature that this scaffold is biologically significant and synthesis of new derivatives can lead to potential molecules to show various biological activities.

3.   Scientific Objectives

Following are the main objectives of the project

1-Synthesis of new 2-arylbenzothiazoles derivatives.

2-Characterization of synthesized compounds using modern spectroscopic techniques.

3-Scientific publications (s) in the impact factor journals.