Carbohydrazide derivatives are known to be antimalarial, antitubercular, antitumor, agonist and anticancer agents. Keeping in view their potential utility, we want to synthesize novel building blocks of substituted carbohydrazide. Such building blocks can be incorporated in various biologically active molecules also in some secondary structures of proteins (beta-sheets). As these building blocks can mimic the donor acceptor behavior of naturally occurring peptides, they can potentially play significant role in the folding pattern of secondary structures of proteins. A facile synthetic route for the synthesis of this substituted carbohydrazide building blocks will be optimized and the key intermediates will be fully characterized using various analytical techniques like IR, NMR, and HRMS.

coumarins are natural fluorophores are used as light emitting diodes. On the other hand Oxadiazoles, Triazoles and pyrazoles are also known for their florescence activities  can be used as detectors etc. In view of their industrial and medicinaly significance the aim and objective of the present research is to synthesized some coumarin substituted Oxadiazoles, tiazoles and pyrazoles and check them for their UV studies.

Project describes the synthesis of some five membered heterocycles starting from their common precursor hydrazides some 1,3,4-Oxadiazoles, 1,2,4-triazoles and 3,5-disubstituted pyrazoles will be synthesized and then will be subjected to their biological activities. Structures of all the synthesized compounds will be conform by using IR, ¹HNMR, ¹³CNMR and Mass analysis

Synthesis and photophysical of substituted titanium phthalocyanines containing tetracyanoquinodimethane (TCNQ) and its derivatives at axial position, capable of absorbing at longer wavelengths with high molecular extinction coefficient. The photophysical chareacterization of synthesized Pcs by means of steady state and time resolved photophysical techniques, will be accomplished to evaluate the applications of synthesized compounds in dye sensitized solar cells.

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A Facile Enantioselective Synthesis of (+)-(R)-Concentricolide (A Natural Alkaloid).

In the fast-developing field of nanotechnology, gold nanoparticles (Au-NPs) have served as a versatile platform for exploring many facets of basic science. Conjugation of Au-NPswith oligosaccharide, DNA, proteins, or small bio-functional molecules also find applications in biology.

Synthesis of Biologically Active Coumarin Derivatives by Palladium Catalysed Cross Coupling Reaction

Hydrazones and their metal complexes posses’ wide spectrum of pharmacological analytical, magnetic and optical applications. Hydrazones and their metal complexes are being used against various pathogens; therefore, synthesized hydrazones and their metal complexes can be potentially active and will be fully Characterized using different modern instrumental techniques such elemental analysis (C.H.N.),¹H NMR, ¹³C NMR, FTIR, UV/Visible spectroscopy, magnetic susceptibility, X-Ray crystallography, thermogravimetric analysis (TGA) and fluorescence properties. Synthesized compounds will also be screened for their pharmacological potential against various pathogenic strains i.e. bacterial and fungal strains.

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With the increase in antibacterial drug development resistance of bacteria against the antibacterial drugs is increasing day by day. This problem has triggered the attention of the scientists to introduce new antibacterial drugs. Carboxylic acid substituted Quinolone derivatives are famous for their broad spectrum activities as antimicrobial agents. They are active against the both gram negative bacteria as well as gram positive strains of bacteria. The current project is about the synthesis of some quinolone carboxylic acid substituted oxadiazole, triazoles and triazole amine starting from their common precursor hydrazides. Structures of all the synthesized compounds will be confirmed by IR, ¹HNMR,¹³CNMR spectral analysis. As literature reveals the antibacterial significance of the quinolone carboxylic acids, all the synthesized compounds will subjected to their antibacterial assays against the gram positive and gram negative strains of bacteria.

Synthesis of 4-aminoantipyrine based Schiff Bases and their metal complexes are of interest due to their potential as biologically active molecules. Schiff bases and metal complexes are currently used against various pathogens; therefore, synthesized ligands and their metal complexes can be potentially active and will be fully characterized using different modern instrumental techniques such elemental analysis (C.H.N.), ¹HNMR, ¹³CNMR, FTIR,UV/Visible spectroscopy, magnetic susceptibility, X-Ray crystallography, thermal studies and fluorescence properties. Synthesized compounds will also be screened for their pharmacological potential against various pathogenic strains i.e. bacterial and fungal strains.

Fluorescence-based analytical tools are becoming very attractive for rapid detection of explosives. Fluorescence emission is very sensitive phenomena and any change in fluorescence emission can be observed upon interactions of fluorescence probes with analytes present in the explosives. Explosive molecules are extremely electron deficient materials due to the presence of electron withdrawing groups such as nitro group. Such electron deficient molecules can easily interact and bind with electron-rich fluorescent molecules (fluorophors). Fluorescence of a fluorphore can be quenched through molecular interactions between the fluorophore and specific explosive material. The oxidation and reduction potentials would predict the direction of electron flow. Energy of ground state orbitals and excited state orbitals would also predict the direction of photo-induced electron transfer. With this in mind, π-electron rich tetraphenyethylene and fluorene-based conjugated polymers are designed. Electron rich conjugated polymers will provide basis for contact with electro-deficient explosive molecules through the donor-acceptor (D-A) interactions. A conjugated polymer with fluorene backbone and phenylene as spacer units is designed for rapid detection of ultra-trace analytes from explosive molecules. Sterically large adamantane group and pyrene moiety will serve as bulky side chains which will impart desired properties to the proposed polymers. A library of relevant fluorescent polymers will be generated by varying size of side chains.

The wide-ranging and potent activity of benzofuran has recognized as one of the biological important scaffold. This project is covered the methods for the synthesis of benzofurans and its related heterocycles, structure activity relationship and pharmacological activities. It is an effort to highlight the significance of the benzofuran in the present perspective and promise they hold for the future. The project will focus on using substituted alkenes as substrates for generating heterocycles such as dihydropyrimidines and benzofurans. An activation of substituted alkenes with selenium and palladium reagents will give rise to either cyclic compounds or desired functionalization of alkenes. This study will represent our initial effort toward the synthesis of benzofurans and dihydropyrimidines. Once an initial method has been identified, a variety of substrates have to be undertaken in order to bring the desired synthesis to useful levels.

In present research, various ligands are planned from commercially available chemicals. Treatment of substituted benzonitriles with hydroxylamine hydrochloride in the presence of sodium carbonate using ethanol / methanol as solvents will furnish N-hydroxybenzamidines in good yields. Upon further treatment of N-hydroxybenzamidines with various transitions metals under appropriate reaction conditions, a library of target metal complexes was obtained in good yields. After getting encouraging results from metal complexation of benzamidines, another type of organic ligand for example chalcone will also considered to prepare diverse range of metal complexes. For this purpose, various substituted chalcones were formed by treating different acetophenone with suitable benzaldehydes under mild and basic reaction conditions. Furthermore, reaction of various metal (II) chlorides / nitrates with various analogues of chalcones under reflux reaction conditions will provide new metal complexes in good yields. Finally, detailed chemical structures of synthesized compounds were characterized through spectroscopic methods such as FTIR, ¹H NMR and ¹³C NMR spectroscopy. Their role in paint will be studied as a antibacterial materials.

Economy of Pakistan heavily relies on its agriculture which includes wheat, cotton, maize, etc., as the major crops. Wheat (Triticum aestivum L.) is a key cereal and an essential food crop which plays the significant role in the economy of Pakistan.1,2 Unfortunately the problem associated with this crop is with the yield i.e., obtained yield is always less than that of the expected. The factor which are responsible for less yields are unavailability of water, inadequate land, lack of modern technology awareness and no education about the insecticides and pesticides. Collectively all these factors are not only responsible for less yield but also impart negative effects.1 Wheat crop suffers a substantial clang in yield because of aphid attack.2 Another factor responsible for the low yield is plants fungal diseases like Spot Blotch (SB), yellow and brown rusts diseases caused by fungus infections.3 The increase in the Global population has increased the demand to produce more safe foods. So, dependence of farmers on different pesticide to control pathogens, weed and the insects that compete for these foods remains a vital and endless necessity.4 Many synthetic chemical pesticides play critical parts in wheat protection, however, frequent practice of these traditional pesticides has led to the pest resistance. Moreover, they also pose side effects on environment and non-target organisms. Thus, there is a continuous need of agrochemical alternative’s discovery with low mammalian toxicity, effective, selective, and ecofriendly to address the problems associated with pest control.5 In crop protection, thiourea and acylthiourea have been reported to display a variety of biological activities, such as insecticidal, fungicidal and herbicidal activities.6 With all this in mind, the current proposal is to introduce thiourea and acylthiourea groups into benzothiazole structure as linker and then to investigate them for their insecticidal bioactivity for the sustainable growth of wheat crop. We believe that such projects are not only important to create further knowledge in the field but have direct impact on sustainable development by finding the indigenous solution to our indigenous problems.