The wide-ranging and potent activity of benzofuran has recognized as one of the biological important scaffold. This project is covered the methods for the synthesis of benzofurans and its related heterocycles, structure activity relationship and pharmacological activities. It is an effort to highlight the significance of the benzofuran in the present perspective and promise they hold for the future. The project will focus on using substituted alkenes as substrates for generating heterocycles such as dihydropyrimidines and benzofurans. An activation of substituted alkenes with selenium and palladium reagents will give rise to either cyclic compounds or desired functionalization of alkenes. This study will represent our initial effort toward the synthesis of benzofurans and dihydropyrimidines. Once an initial method has been identified, a variety of substrates have to be undertaken in order to bring the desired synthesis to useful levels.