An agricultural country, Pakistan is highly dependent on the Indus irrigation system, one of the largest irrigation networks in the world. The Indus River catchment area, upstream of Tarbela reservoir, is called the Upper Indus River basin (UIB), which contributes the main inflow to the Indus River at high elevations as a result of snow and glacier melt. Seasonal variation of the snow and glacier cover (resulting from change in climate variables) influences directly the stream flow in the Upper Indus River. It is, therefore, important to monitor the impacts of climate change on the cryosphere melt in snow-fed catchments for several purposes such as hydrometeorology, flood forecasting and water resource management. The hydro-meteorological and snow cover investigations based on the ground data are very difficult in these regions. Satellite remote sensing is a powerful tool to estimate the snow and glacier (cryosphere) covered area in remote and inaccessible areas. MODIS (MOD10A2) snow cover satellite product over a period of 14 years (2000 to 2013) and hydro-meteorological data of various gauging stations will be used to estimate the climate variability impacts on snow and glacier cover trend and hydrology of the Shigar River basin (a sub-catchment of the UIB), situated in the Karakoram range – Northern Pakistan.