Drug development has been a principal driving force in the rapid maturation in the field of medicinal chemistry during the past several decades. Conjugated heterocyclic compounds possess extended π-systems have received substantial attention due to their synthetic and effective biological significances. Heterocycles bearing 1,3,4-oxadiazoles are reported to demonstrate a broad spectrum of pharmacological properties such as anti-depressant, antimicrobial, anticancer, anti-inflammatory, anticonvulsant, analgesic, antitubercular and anti-HIV activities

Based on these facts, designing of new chemical entities with potential biological effects require simulation of a suitable bioactive pharmacophore. The pharmacophore should not only require potency but must also be safer. In this perspective, the aim of current project is the synthesis of Oxadiazoles based Mannich Bases in order to explore the bioactivity profile as anti-depressant agent which may open up new opportunities for further investigations in one of the most vibrant and promising areas of research.