Antibiotic resistance causes impairment to human health and increases the mortality rate. Antibiotic resistance is expanding globally, making the current commercially available antibiotics out-dated to control bacterial infections. Resistance to antibiotic is spreading rapidly as compared to the introduction of new antibiotics. Treating antibiotic resistant bacterial strains is becoming difficult because pathogens have different physiological and biochemical characteristics hence, a single compound is not sufficient for treating all antibiotic resistance. Drug resistance emphasizes on isolation of novel antibiotic producing strains. Numerous unexploited microorganisms are found in soil that needed to be exploited. Soil represents a rich source for soil borne microorganism and also there is need to capitalize microbe’s ability to produce new compound.Antibiotic resistance causes impairment to human health and increases the mortality rate. Antibiotic resistance is expanding globally, making the current commercially available antibiotics out-dated to control bacterial infections. Resistance to antibiotic is spreading rapidly as compared to the introduction of new antibiotics. Treating antibiotic resistant bacterial strains is becoming difficult because pathogens have different physiological and biochemical characteristics hence, a single compound is not sufficient for treating all antibiotic resistance. Drug resistance emphasizes on isolation of novel antibiotic producing strains. Numerous unexploited microorganisms are found in soil that needed to be exploited. Soil represents a rich source for soil borne microorganism and also there is need to capitalize microbe’s ability to produce new compound.